Immunotherapy with a modified birch pollen extract
Glutaraldehyde-modified extracts reduce the risk of side effects without reducing the immunogenic properties. Several studies showed that the clinical efficacy of modified allergen extracts is retained and that such preparations are safer than nonmodified extracts.The aim of this study was to show in a multi-centre, randomized, placebo-controlled double-blind setting the efficacy and safety of immunotherapy with glutaraldehyde-modified aluminum hydroxide-adsorbed extract of birch pollen. The findings of this study indicate that immunotherapy with a modified slow-release birch pollen extract, administered in a single-strength preparation with a rapid dose increase, is safe and efficacious. IgG and IgG4 antibodies against native Bet v 1 are induced.
